LUTEAL PHASE STIMULATION AFTER FOLLICULAR PHASE STIMULATION DURING THE SAME MENSTRUAL CYCLE (DUOSTIM) IN A REDUCED OVARIAN RESERVE POPULATION: WHEN IS IT COST-EFFECTIVE?

To compare the number of eggs, mature eggs and blastocysts obtained during stimulation in follicular phase (FP) versus stiulation luteal (LP) same menstrual cycle (DUOSTIM) patients with decreased ovarian reserve according to count visible antral follicles (AF) at time first oocyte retrieval. It was a Prospective paired observational study. From January 2020 March 2021, forty-nine women who would be submitted vitro fertilization embryo freezing. inclusion criterion AF less than 7. All underwent two cycles stimulation, one FP other LP. Both stimulations were performed gonadotropin-releasing hormone antagonist protocol using 300 IU recombinant FSH 75 LH. (FPS) has started on day 2 LP (LPS), 5 days after During retrieval, counted (2 9 mm). These not aspirated. FPS LPS compared mean blastocysts. In second analysis, separated into groups: Group 1: egg retrieval this moment. 2: count, collection, equal or greater obtained. The parameters analyzed by comparing for each group. FPS, it required 11.01 3.96 2.67 0.83 LPS, 13.53 necessary 5.10 3.80 1.35 results statistically significant. Analyzing group 1 separately, (5.70), (4.48) (1.57) (3.39, 2.13 0,64, respectively), all also significantly higher (12.87 vs 11.04). 2, 4.46 3.15 1.12 4.08 2.81 0.88 (not significant), Greater (14.07 11.02, p <0.05). low reserve, leads embryos previous when collection is exceeds When obtained, does increase blastocysts, hand, requires more and, therefore, cost. case, cost-effective.